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Provide a critical appraisal of the following paper. de Araújo TV, Rodrigues LC, de Alencar Ximenes RA, et al. Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study. Lancet Infect Dis. 2016 Dec;16(12):1356-1363. Address the below questions in your response. Unlike the short question and answer format of exercise 5, for this assessment please synthesise your answers to the questions in an essay format including an Introduction and Conclusion. What is the purpose of the study? (2 marks) What is the study design? Is this an appropriate study design for the purpose of the study? Justify your answer. (3 marks) Describe the sample. What is the target population? (4 marks) How was the matching done? Was this approach appropriate? (4 marks) What are the study factors? How was information on these obtained? (4 marks) What are the outcome factors? How was information on these obtained? (4 marks) Did the researcher identify potential confounders in this study and if so, how did they deal with them (3 marks) Identify potential biases in this study. (2 marks) What statistical methods were used? Were these appropriate? (3 marks) Describe the study strengths/weaknesses/limitations. (5 marks) What are the main results from this study? (2 marks) Taking into consideration the study strengths and weaknesses, do you think they are valid? (3 marks) What are the authors’ conclusions? Do you agree with them? (3 marks) Assuming that the results of this study are valid, what do you think are the most important public health implications from this paper? (3 marks)